Vitaliy Vasylyovych Mandzyuk (born 24 January 1986 in Vilino, Crimea) is a retired Ukrainian football defender who last played for Dnipro Dnipropetrovsk in the Ukrainian Premier League.
Previously he played for Dynamo Kyiv and was on loan to Arsenal Kyiv.
He is a former player for the Ukraine national under-21 football team having made 12 appearances and the senior team.
He is younger brother of the player of Oleksandr Mandzyuk.