Didier Le Guillou (born 1 April 1960) is a retired French middle-distance runner who competed primarily in the 800 metres. He reached the semi-final at the 1982 European Championships and the heats at the 1983 World Championships.
He became French indoor champion in 1983.His personal best time was 1:46.36 minutes, achieved in July 1983 in Bordeaux.